Berberine is the main chemical active ingredient extracted from Coptis Chinensis and Cortex Phellodendri Chinensis.It has many pharmacological effects such as antibacterial,anti-gastric ulcer,anti-tumor,lowering blood sugar,lowering blood lipids,and anti-cardiovascular and cerebrovascular diseases.However,the poor water solubility and low bioavailability of berberine limit its development and application.Nanopreparation has the advantages of small particle size and large specific surface area.It can enhance drug efficacy,improve the oral absorption of insoluble drugs,and achieve slow and controlled release of drugs.In this paper,the research of berberine nanopreparations is reviewed,which provides ideas for the development and application of berberine nanopreparations.
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