Gas Chromatography to Determine Memantine Hydrochloride Related Substances
A 5%phenyl-95%methylpolysiloxane capillary column(HP-5,50 m×0.32 mm×0.52 μm)was used in this study,the flow rate was 4 mL/min,the direct injection was 1.0 μL,the inlet temperature was 220℃and the detector temperature was 300℃.Under this chromatographic condition,the separation between the impurity peaks is good,the blank does not interfere with the detection of related substances,and can be used for the detection of memantine hydrochloride related substances.
gas chromatographymemantine hydrochloridedetermination of related substances
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