Study on Preparation of Adefovir Dipivoxil Tablets
Objective:To optimize the formulation of adefovir dipivoxil tablets.Methods:The uniform design method was adopted,with the proportion of filler as factor A,disintegrant as factor B,lubricant as factor C,and dissolution similarity factor as the index.Results:The optimal conditions were the ratio of fillers(lactose and pregelatinized starch was 2.6),disintegrators(5.2％crosslinked povidone)and lubricants(0.5％calcium stearate).f2 of the 3 batches of verification tests were all greater than 50,similar to the dissolution behavior of the reference preparation,and the average cumulative dissolution rate was more than 90％.Conclusion:The prescription was reasonable in design,easy to operate and had good dissolution in vitro.
NETL
NSTL
万方数据
