阿德福韦酯片的制备研究
Study on Preparation of Adefovir Dipivoxil Tablets
陈仲祥 1周成林 2王书兰 2尹可欣 2李禄年 3熊莉平2
作者信息
- 1. 重庆工信职业学院,重庆 401233
- 2. 西南药业股份有限公司,重庆 400038
- 3. 太极集团有限公司,重庆 401120
- 折叠
摘要
目的:优化阿德福韦酯片的处方.方法:采用均匀设计法,以填充剂比为因素A,崩解剂为因素B,润滑剂为因素C,以溶出度相似因子作为考察指标.结果:最优化的条件为填充剂比(乳糖、预胶化淀粉比为2.6),崩解剂(5.2％交联聚维酮),润滑剂(0.5％硬脂酸钙),3批验证试验的f2均大于50,与参比制剂溶出行为相似,平均累积溶出度90％以上.结论:该处方设计合理,易于操作,体外溶出度良好.
Abstract
Objective:To optimize the formulation of adefovir dipivoxil tablets.Methods:The uniform design method was adopted,with the proportion of filler as factor A,disintegrant as factor B,lubricant as factor C,and dissolution similarity factor as the index.Results:The optimal conditions were the ratio of fillers(lactose and pregelatinized starch was 2.6),disintegrators(5.2％crosslinked povidone)and lubricants(0.5％calcium stearate).f2 of the 3 batches of verification tests were all greater than 50,similar to the dissolution behavior of the reference preparation,and the average cumulative dissolution rate was more than 90％.Conclusion:The prescription was reasonable in design,easy to operate and had good dissolution in vitro.
关键词
阿德福韦酯片/均匀设计/相似因子Key words
adefovir dipivoxil tablets/uniform design/similarity factor引用本文复制引用
基金项目
2022-2023年重庆市职业教育学会课题项目(2022ZJXH431032)
出版年
2024
NETL
NSTL
万方数据