a-Acetyl-y-butyrolactone was used as the starting material to react with methyl iodide to synthesize compound Ⅱ;Compound Ⅱ reacts with hydrobromic acid to hydrolyze brominated to synthesize compound Ⅲ;Compound Ⅲ is then reacted with bromine to obtain dibrominated product Ⅳ;Compound Ⅳ is closed with benzylamine to obtain compound Ⅴ;Compound Ⅴ was catalyzed by transaminases,and methylamine was used as the ammonia source,and compound Ⅰ with an ee of more than 99.5％was obtained.The effects of catalyst,enzyme catalyst,molar ratio and reaction temperature on the reaction were studied,and the recovery and utilization of hydrobromic acid and bromine were studied.The results showed that the optimal process conditions for compound Ⅱ were sodium carbonate as catalyst and methyl iodide as methylation reagent;Optimal process conditions for compoundⅢ:hydrobromic acid acts as both a reaction reagent and a solvent;The optimal process conditions for compound Ⅳ were the dibromine product obtained by bromine bromide under acidic conditions,the optimal process conditions for compound Ⅴ were direct reaction with benzylamine to obtain the product,and the optimal process conditions for compound Ⅰ were enzymatic conversion to obtain chiral products at room temperature.
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