Current Status and Prospects of PARP Inhibitors in Breast Cancer Applications
PARP inhibitors can produce inhibitory effects on malignant tumors through mechanisms such as synthetic lethality and PARP-DNA capture,and have made great progress in the treatment of patients with a variety of malignant tumors,including breast cancer.In this paper,we briefly review the BRCA gene and breast cancer,the anti-tumor molecular mechanism of PARP inhibitors and their application in breast cancer,with a view to improving the understanding of PARP inhibitors and providing references for future clinical applications.
breast cancerPARP inhibitormolecular targeted therapy
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