Construction and Characterization of the Curcumin Loaded Lipid-polymer Hybrid Nanoparticles
The clinical application of curcumin in the field of cancer therapy has been hindered by the problems such as poor water solubility,poor stability and low bioavailability.Based on the the weakly acidic environment of tumor tissue and the reductive environment of tumor cells,an amphiphilic polymer with both reduction sensitivity and charge reversal properties was designed and synthesized.Then the lipid-polymer hybrid nanoparticles(LPNPs)with good uniformity and appropriate particle size were prepared by the self-assembly of this amphiphilic polymer,phosphatide and polycaprolactone(PCL),which could effectively load the anti-tumor drug curcumin with a high drug loading content(DLC:6.78％)and entrapment efficiency(EE:92.3％).The nanoparticles are negatively charged under normal conditions,which ensures the low adsorption of protein in the blood and excellent hemocompatibility.In a weakly acidic environment(pH value 6.5),the surface charge of the nanopariticles convert to positive,facilitating the uptake of the nanoparticles by cancer cells.There are significant changes in the particle size and particle size distribution of nanoparticles under the simulated reducing conditions,indicating the good reduction sensitivity of the nanoparticles,which guarantees the triggered drug release in response to tumor microenvironment.The intelligent nanocarrier reported in this paper provides a new method for the efficient delivery and controlled release of anti-tumor drugs.
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