首页|竞争性吸附法降低林可霉素B组分的工艺研究

竞争性吸附法降低林可霉素B组分的工艺研究

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生产林可霉素的传统工艺为萃取法,该方法不能有效去除B组分杂质,目前较新颖的树脂法虽能将B组分去除,但效率不够高。本文以竞争性吸附原理为指导,通过连续上柱的方式,放大树脂对产品与杂质的分离能力,从而实现了 B组分的高效去除。本研究也为竞争性吸附法在其他生化产品分离领域的应用提供了借鉴。
Study on the Process of Reducing Lincomycin B Component by Competitive Adsorption Method
The traditional process of lincomycin production is extraction method,which can not effectively remove the B component impurities,although the current resin method can remove the B component,but the efficiency is not high.In this paper,based on the principle of competitive adsorption,the separation ability of the resin to the product and impurities was amplified by the way of continuous column,and the efficient removal of B component was realized.This study also provides a reference for the application of competitive adsorption method in the separation of other biochemical products.

competitive adsorptionseries chromatographylincomycin

吕祖平、胡晓霞

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台州市厚普生物科技有限公司,浙江台州 318000

联化科技(台州)有限公司,浙江台州 318020

竞争性吸附 串联层析 林可霉素

2024

山东化工
山东省化工研究院 山东省化工信息中心

山东化工

影响因子:0.249
ISSN:1008-021X
年,卷(期):2024.53(13)