Urinary trypsin inhibitor(UTI),isolated and purified from human urine,is a small chondroitin sulfate proteoglycan with Ser-proteinase inhibitory activity.UTI have good inhibitory effects on proteases such as trypsin,hyaluronidase,neutrophil elastase,and plasmin,and have been widely used in clinical treatment of acute pancreatitis,and rescue medication for acute circulatory failure.In present review,the sources,structure,physiological functions,conventional separation and purification processes,and the emerging trends in genetic engineering methods of UTI are summarized,in order to provide consultation for the high-quality production and application of UTI.
关键词
尿胰蛋白酶抑制剂/丝氨酸蛋白酶抑制活性/分离纯化/基因工程技术
Key words
urinary trypsin inhibitor/ser-proteinase inhibitory activity/separation and purification/genetic engineering technology
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