Research Progress in Separation and Purification of Urinary Trypsin Inhibitor
Urinary trypsin inhibitor(UTI),isolated and purified from human urine,is a small chondroitin sulfate proteoglycan with Ser-proteinase inhibitory activity.UTI have good inhibitory effects on proteases such as trypsin,hyaluronidase,neutrophil elastase,and plasmin,and have been widely used in clinical treatment of acute pancreatitis,and rescue medication for acute circulatory failure.In present review,the sources,structure,physiological functions,conventional separation and purification processes,and the emerging trends in genetic engineering methods of UTI are summarized,in order to provide consultation for the high-quality production and application of UTI.
urinary trypsin inhibitorser-proteinase inhibitory activityseparation and purificationgenetic engineering technology
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维普
