4-methylsulfonyl-2,3-dimethylbromobenzene was established by reverse high performance liquid chromatography(HPLC)with V(acetonitrile)∶V[phosphoric acid water(pH value=3)solution]=40∶60 as mobile phase and wavelengthλ=255 nm using an eighteen-alkyl silane-bonded silica gel as filler and a tunable wavelength UV detector.The results showed that the linear correlation coefficient under the method was 0.999 7,and the intermediates had a good linear relationship in the range of 196.9～1 378 µg/mL,with a standard deviation of 0.12,a coefficient of variation of 0.12％,and a recovery rate of 99.46％,which could meet the qualitative and quantitative analysis of 4-methylsulfonyl-2,3-dimethylbromobenzene,and the results were presentable.
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维普
