Study on Preparation of Eperisone Hydrochloride Tablets
Objective:To optimize the formulation of eperisone hydrochloride tablets.Methods:The orthogonal design method was used,with the proportion of filler as factor A,the lubricant as factor B,the average hardness of the tablets as factor C,and the dissolution similarity factor as the index.Results:The optimal conditions were as follows:the proportion of filler(m(corn starch)∶m(microcrystalline cellulose)=20∶20),lubricant(1％Sodium Stearyl Fumarate),average hardness(40 N),f2 of 3 batches verified were all greater than 50,which was similar to the dissolution behavior of the reference preparation.Conclusion:The prescription was reasonable in design,simple in process,easy to operate and good in vitro dissolution.
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