Simultaneous Determination of 47 Anti-infective Drugs in Cosmetics by UPLC-MS/MS
To simultaneous determine 47 kinds of anti-infective drugs in cosmetics with three matrix types(water,emulsion,cream)by ultra high performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS).The sample was dispersed by saturated sodium chloride,and then was ultrasonically extracted with methanol.And each component was quantified by an external standard curve with matrix.The results:47 kinds of anti-infective drugs showed good linear relationships in their respective linear concentration ranges.The limits of detection(LODs)were 0.02～0.47 μg/kg,and the limits of quantitation(LOQs)were 0.10～2.37 μg/kg.The average recoveries at three spiked levels were 80.7％～119.8％,with the relative standard deviations(RSD)not greater than 10.0％.This method has the advantages of simple pretreatment,high response,accuracy and reliability.It can be used for the rapid and accurate qualitative screening and quantitative determination of 47 anti-infective drugs in cosmetics.
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