In response to the problems of complex process,high energy consumption,and high environmental pressure in the Friedel-Crafts acylation reaction of traditional ibuprofen production process,this study applies solvent-free continuous flow synthesis technology to the Friedel-Crafts acylation reaction of 2-chloropropionyl chloride and isobutylbenzene.A solvent-free continuous flow reaction system is designed,the process is optimized and the best production conditions are obtained by examining factors such as residence time,temperature,total flow rate,and molar ratio.The safe and effective preparation of high-quality aromatic ketones in the continuous flow synthesis reaction of highly corrosive vapor-liquid mixtures is achieved,with the conversion rate of isobutylbenzene and the purity of aromatic ketones reaching about 99％.This study provides a reference basis for the same series of studies on continuous flow synthesis processes and related Friedel-Crafts acylation reactions in the field of drug synthesis.
关键词
Friedel-Crafts酰化反应/无溶剂连续流反应/优化工艺/转化率
Key words
Friedel crafts acylation reaction/solvent-free continuous flow reaction/optimize the process/conversion rate
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