Research Progress on Preparation Technology of Recombinant Collagen
Collagen is a biofunctional protein that has been widely used in many fields,including but not limited to biomedical,cosmetics and skin care,food,and novel materials.Recombinant collagen has great potential as an alternative to collagen extracted from animals because it avoids the immune response,also the yield and properties are stable.However,recombinant collagen still faces challenges in industrial applications such as low expression,high cost in industrial production and difficult hydroxylation.This paper focuses on the key factors affecting the yield of recombinant collagen fermentation,and obtains the appropriate control conditions for each key factor based on the domestic and foreign experimental researches.The common preparation technology and mechanism of recombinant collagen purification process were introduced,and the practical effect of each process on the extraction of recombinant collagen was discussed with examples.Finally,the optimization of fermentation and purification process of recombinant collagen was prospected.
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