Study on the Mechanism of Action of Chenxiang Siwei Powder in the Treatment of Ischemic Heart Disease
Objective:To investigate the mechanism of action of Chenxiang Siwei powder in the treatment of ischemic heart disease(IHD).Methods:The active ingredients and targets of Chenxiang Siwei powder for ischemic heart disease were screened by the TCMSP platform,and IHD targets were searched by Genecards,OMIM,and TTD data platforms,the protein interaction network between Chenxiang Siwei powder and IHD targets was constructed,the key targets were extracted,and GO and KEGG enrichment analyses were performed.Results:28 pharmacodynamic components,226 pharmacodynamic targets,1 570 disease targets,196 key targets for drug treatment of ischemic heart disease,and 169 KEGG pathways were obtained.Conclusion:The core components of Chenxiang Siwei powder for the treatment of IHD are quercetin,β-sitosterol,kaempferol,naringenin,(2-phenylethyl)chromones,and the core targets are NTRK1,APP,TP53,EGFR,CUL3,ESR1,UBC,and FN1,which preliminarily revealed the mechanism of action of Chenxiang Siwei powder for the treatment of IHD,and provided a basis for the clinical development and utilization of Chenxiang Siwei powder.It will provide a basis for the clinical development and utilization of Chenxiang Siwei powder.
万方数据
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