Synthesis and Anti-Cervical Cancer Activity of Carbotrizole-1,2,3-Triazole Derivatives
Cervical cancer is a common cancer among women,but current treatment methods have significant side effects and limited efficacy in treating advanced cervical cancer.Therefore,there is an urgent need to develop better treatment methods for cervical cancer.In this study,based on the structure of cabotegravir,1,2,3-triazole with substituted group 2-ethylphenyl,3,5-difluoromethylphenyl,2-trifluoromethoxyphenyl,2,5-difluoromethylphenyl,or 2,4,6-trimethylphenyl was introduced to obtain 5 derivatives by click chemistry.The compounds were characterized using 1H NMR and 13C NMR spectroscopy.Furthermore,the Hela cervical carcinoma cell line was used as the research object to observe the anti-cervical cancer activity of the derivatives.MTT assay was employed to detect the survival rate of Hela cells after treatment with the derivatives.The results showed that all the derivatives exhibited good anti-proliferative activity against Hela cells.Among them,compound C5 showed the best activity,with a cell survival rate of 69.18％±1.08％at a concentration of 10 μmol/L,indicating its potential for the treatment of cervical cancer.
万方数据
维普
