Study on the Preparation Process of Compound Sodium Acetate Ringer's Injection
Objective:To optimize the preparation technology of Compound Sodium Acetate Ringer's Injection.Methods:The character,pH,5-hydroxymethyl furfural and glucose content of the injection were used as indexes,the pH value,solution temperature,membrane material,sterilization process and packaging form were investigated by single factor method.Results:The optimal process was 80 ℃ dissolved calcium gluconate,pH of injection was adjusted to 6.1,and an external barrier bag of 121 ℃was added to the non-P VC three-layer co-extruded film soft bag to sterilize the injection for 15 min,the Compound Sodium Acetate Ringer's Injection is obtained.Conclusion:The optimized preparation technology is feasible and the product quality is stable,which can provide a basis for the industrial development of Compound Sodium Acetate Ringer's Injection.
compound sodium acetate ringer's injectionpreparation processsingle factor test
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