A Novel Compound of 3-(3,4-dihydroxyphenyl)-2(1H)-Quinoxalinone Ameliorating Diabetic Nephropathy with Hypoglycemia and Antioxidant Effects
Objective:diabetes nephropathy(DN)is the main cause of end-stage renal disease and one of the most intractable complications of diabetes.The accumulation of reactive oxygen species(ROS)leads to oxidative stress that promotes the development of DN:Therefore,clearing ROS is a key method for preventing and treating DN.Method:3-aryl quinoxalone derivatives were prepared.By measuring urine protein,malondialdehyde level,renal glutathione level and superoxide dismutase activity,the improvement effect of the compound on DN was determined.Results:3-(3,4-dihydroxyphenyl)-2(1H)-quinoxalinone can reduce the levels of urine protein,MDA,increase the level of GSH and SOD activity in the kidney of diabetes nephropathy mice,which confirms its significant antioxidant effect,improving proteinuria.Conclusion:The above results indicate that this compound has a potential role in improving kidney damage caused by DN.
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