Advances in the Study on the Hazards and Determination Methods of Oxalate
Oxalic acid forms calcium oxalate in the body,which leads to stones,Hypercalcemia,hyperoxaluria,hypocitruria,and low urine output are the main diseases caused by increased mineral supersaturation and calcium oxalate formation.In this paper,the existence and hazards of oxalate are introduced,and the research on the determination method of oxalate is introduced.Taking several oxalate detection methods as examples,this article compares visual colorimetry,spectrophotometry,ion chromatography,and high-performance liquid chromatography methods from the aspects of method principles,sample preparation,experimental operations,limit control,and precautions.The advantages and disadvantages of each method are listed,providing reference for oxalate analysis and detection.Combining the testing methods in the draft national drug standard for calcium gluconate and the quality standards and control of oxalate in various parts of the 2020 edition of the Chinese Pharmacopoeia,the necessity of oxalate in drug quality control is elaborated,and the trend of improving the precision and accuracy of testing methods based on product quality control to meet the requirements of current technical guidelines is clarified.
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