Objective:Ibuprofen tablets have been shown to be effective in the treatment of colds,fevers,and joint pain,while ibuprofen tablets have been shown to be effective in the treatment of joint pain.Especially in the new coronavirus infection,can play a very good role in antipyretic.In order to better control the stability of ibuprofen tablets production,to determine whether ibuprofen tablets in the long-term storage process of new impurities produced,a method for the determination of related substances in ibuprofen tablets was established.Methods:YMC column(4.6 mm× 150 mm,5 µm)was used,0.07％phosphoric acid solution-acetonitrile(55∶45)(the ratio can be adjusted according to the retention time)was used as mobile phase.The column temperature was 30 ℃,the detection wavelength was 214 nm and the flow rate was 1.0 mL/min.The results showed that the RSD of quantitative limit and detection limit was less than 5.0％;specificity:Excipients did not interfere;the separation between main peak and miscellaneous peak was good.The repeatability and intermediate precision RSD were both less than 1.0％;Accuracy:Different concentrations of ibuprofen are added to the test solution,the recovery rate is more than 90％.Stability:The control solution and test solution under natural conditions,placed for 8 h,test solution no new substances generated,the stability of the solution is good.Durability:When the chromatogram condition changes in a certain range,compared with the standard condition,the change is within the specified error range,in line with the system applicability test requirements.Linear and range:The linear result of ibuprofen is linear with the concentration of the sample in the specified range,and the linear range can meet the requirements of precision and accuracy.
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