The problems existing in the traditional synthesis process of 4-chloro-4'-hydroxybenzophenone,the key intermediate of fenofibrate,were optimized,and the synthesis route with high industrial application value was found through experimental exploration:p-chlorobenzoyl chloride and anisole were used as raw materials,and the target product was obtained after post-treatment,with a total yield of 92％and a purity of 98.5％.The route is simple,mild,economical,environmentally friendly,and has high yield and cost.
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