喹硫平合并奥拉西坦对老年精神分裂症认知功能的影响
Effect of oxiracetam adjunctive treatment with quetiapine on cognitive impairments in aged patients with schizophrenia
顾培 1汪敬 1李宝珠 1曹江1
作者信息
摘要
目的 研究奥拉西坦对老年精神分裂症患者认知功能的治疗效果.方法 将48例老年精神分裂症患者随机分为喹硫平联合奥拉西坦组(研究组)24例和喹硫平组(对照组)24例,分别应用喹硫平联合奥拉西坦和单用喹硫平治疗8周.于治疗前和治疗8周末测定认知功能,用阳性和阴性症状量表(PANSS)于治疗前和治疗8周末评定临床疗效.结果 治疗8周末,两组各认知测验和PANSS分较治疗前均有改善(P＜0.05或P＜0.01)；视觉再生测验、数字广度测验和连线A测验及连线B测验总分变化值研究组高于对照组(P＜0.05或P＜0.01).结论 奥拉西坦可以改善老年精神分裂症患者的认知功能.
Abstract
Objective To study the efficacy of oxiracetam on cognitive impairment in aged schizophrenic patients. Methods A total of 48 aged patients with schizophrenia were randomly divided into study group treated with quetiapine combined with oxiracetam and control group treated with quetiapine monotherapy for 8 weeks. The cognitive function was assessed at baseline and at the 8th weekend. The clinical efficacy was evaluated with Positive and Negative Syndrome Scale ( PANSS). Results At the 8th weekend, scores of cognitive test and PANSS were improved significantly compared with those at baseline ( P < 0.05 or P < 0. 01). Total score of visual reproduction subsets, digit span test, trail making test A and B in study group were significantly higher than those in control group ( P < 0. 05 or P < 0. 01 ). Conclusion Oxiracetam could improve the the cognitive function of aged schizophrenic patients.
关键词
老年精神分裂症/喹硫平/奥拉西坦/认知功能Key words
Aged schizophrenia/Quetiapine/Oxiracetam/Cognitive function引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据