Treatment of low-frequency repetitive transcranial magnetic stimulation over the right parietal lobe of patients with generalized anxiety disorder comorbid with insomnia:A randomized controlled trial
Objective To explore the therapeutic effect and mechanism of low-frequency repetitive transcranial magnetic stimulation(rTMS)over the right parietal lobe in patients with generalized anxiety disorder(GAD)comorbid with insomnia.Methods A total of 60 patients with GAD comorbid with insomnia were selected and randomly divided into study group treated with 20 sessions of 1 Hz rTMS applied over the right parietal lobe(2 000 pulses each time)and control group treated with sham rTMS.The changes of scores of Hamilton Anxiety Scale(HAMA),Pittsburgh Sleep Quality Index(PSQI)as well as the latencies and amplitudes of event-related potentials MMN and P300 before and after treatment were compared;the correlations among each indicators and the improvements were analyzed.Results After treatment,the total scores of HAMA and PSQI as well as the latencies of MMN and P300 in study group decreased significantly,and amplitudes increased significantly compared with those before treatment(P<0.05).In study group,the improvement in HAMA score was positively correlated with improvements in PSQI score and P300 amplitude(P<0.05).Conclusion Low-frequency rTMS over the right parietal lobe is effective in patients with GAD comorbid with insomnia,which could improve the patients'anxiety state,sleep quality and cognitive function.The improvement in P300 amplitude could be used as a biological indicator of anxiety symptom improvement.
Generalized anxiety disorderInsomniaRepetitive transcranial magnetic stimulationEvent-related potentialsRight parietal lobe
万方数据
维普
