摘要
目的 探究双相情感障碍(BD)与广泛性焦虑障碍(GAD)人群之间的心率变异性(HRV)的差异.方法 将57 例BD患者(BD组)和 60 例GAD患者(GAD组)分别开展HRV检测,并对两者的心率变异相关指标 24h全程NN间期的标准差(SDNN-24)、全程NN间期的标准差(SDNN)、全程每 5 min NN间期平均值的标准差(SDANN)、全部相邻NN之差的均方根(rMSSD)、相邻NN之差>50 ms的个数占总窦性心搏个数的百分比(PNN50)、总功率(TP)、低频(LF)、高频(HF)、LF与HF之间的比值(LF/HF)结果进行组间统计差异比较.结果 GAD组病程短于BD组(P<0.01).GAD组的时阈指标SDNN-24、SDANN低于BD组(P<0.01).相关分析结果显示,GAD组病程与TP、LF、HF、SDNN均呈负相关(P<0.05).结论 GAD的自主神经功能失调要比BD患者更加严重;GAD患者的病程会影响其HRV频阈指标.
Abstract
Objective To explore the differences in heart rate variability(HRV)between patients with bipolar disorder(BD)and generalized anxiety disorder(GAD).Methods A total of 57 patients with BD(BD group)and 60 patients with GAD(GAD group)were selected and tested for HRV,and their HRV-related indicators SDNN-24(24 h-standard diviation of NN intervals),SDNN(standard deviation of NN intervals),SDANN(standard deviation of average NN intervals in all 5 min segments of the entire recording),rMSSD(root mean square difference between adjacent R-R intervals),PNN50(percentage of difference between adjacent R-R intervals>50 ms),TP(total power),LF(low-frequency power),HF(high-frequency power),and the ratio between LF and HF(LF/HF)were compared.Results The disease course of GAD group was shorter than that of BD group(P<0.01).The indicators of SDNN-24 and SDANN in GAD group were lower than those in BD group(P<0.01).Correlation analysis showed that the disease course was negatively correlated with TP,LF,HF and SDNN in GAD group(P<0.05).Conclusion The somatoform autonomic dysfunction of GAD patients is more serious than that of BD patients.The disease course of GAD patients can affect their HRV indicators.
基金项目
国家自然科学基金(81771465)
上海市科委中西医引导项目(16411965100)
上海市科委中医引导项目(14401932000)
上海市精神卫生中心院级项目(2016-YJ-04)
上海市精神卫生中心院级项目(2018-YJ-08)
维普
万方数据