The relationship between plasma free mitochondrial DNA copy number and post stroke depression in patients with acute cerebral infarction
Objective To explore the relationship between plasma cell free mitochondrial DNA(cf-mtDNA)copy number and post stroke depression(PSD)in patients with acute cerebral infarction(ACI).Methods A total of 128 ACI patients were selected as the study subjects,of which 42 had PSD and 86 did not.According to the severity of depression,PSD patients were divided into mild group(n=13),moderate group(n=24),and severe group(n=5).The correlations between plasma cf-mtDNA copy number and scores of National Institutes of Health Stroke Scale(NIHSS)and Hamilton Depression Scale-17 items(HAMD-17)were analyzed.Using multivariate logistic regression analysis to identify independent factors affecting the occurrence of PSD.The diagnostic value of plasma cf-mtDNA copy number for PSD was analyzed through receiver operating characteristic(ROC)curve and to calculate the area under the curve(AUC).Results The copy number of plasma cf-mtDNA in PSD patients was higher than that in non-PSD patients(P<0.05).Age,hypertension,NIHSS score,and cf-mtDNA copy number were influencing factors for the occurrence of PSD in ACI patients(P<0.05).The results of multivariate logistic analysis showed that age,NIHSS score,and cf-mtDNA copy number were independent influencing factors for the occurrence of PSD in ACI patients(P<0.05).The correlation analysis showed that the copy number of cf-mtDNA was positively correlated with NIHSS score and HAMD-17 score(P<0.001).The AUC for cf-mtDNA copy number diagnosing PSD was 0.862(P<0.001),with a sensitivity of 87.27%and a specificity of 71.62%.Conclusion The increase in plasma cf-mtDNA copy number is an independent influencing factor for the occurrence of PSD in ACI patients,and has potential value in the diagnosis of PSD.
万方数据
维普
