Therapeutic effect of electroacupuncture combined with Xixiezhouba Recipe on constipation caused by antipsychotics
Objective To explore the therapeutic effect of electroacupuncture combined with Tibetan medicine Xixiezhouba Recipe in the treatment of constipation caused by antipsychotic drugs.Methods A total of 140 cases of antipsychotic related constipation(APRC)were selected and randomly divided into lactulose group,electroacupuncture group,Tibetan medicine group,and electroacupuncture+Tibetan medicine group,with 35 cases in each group.All patients were treated on the basis of conventional oral antipsychotic drugs.The lactulose group was treated with lactulose orally,while the electroacupuncture group was treated with Tianshu,Abdominal Node,and Shangjuxu electroacupuncture therapy.The Tibetan medicine group was treated with Xixiezhouba Recipe orally,while the electroacupuncture+Tibetan medicine group was treated with Tianshu,Abdominal Node,and Shangjuxu electroacupuncture therapy simultaneously.The course of treatment was 8 weeks.After treatment,the clinical efficacy of each group was evaluated.All subjects were assessed with constipation symptom score,Bristol Fecal Trait Scale(BSFS),Constipation Quality of Life Scale(PAC-QOL),Brief Psychiatric Rating Scale(BPRS),and Treatment Emergent Symptoms Scale(TESS)to compare the defecation status,stool traits,mental symptoms,and adverse reactions among the four groups before and after treatment.Results After 8 weeks of treatment,the clinical efficacy of electroacupuncture+Tibetan medicine group was better than those of other three groups(P<0.05).After treatment,the scores of constipation symptoms and PAC-QOL in the four groups significantly decreased,while the BSFS scores significantly improved compared with those before treatment(P<0.05);the BPRS scores of electroacupuncture group,Tibetan medicine group,and electroacupuncture+Tibetan medicine group decreased significantly compared with those before treatment(P<0.05).Compared among groups,the scores of constipation symptoms,PAC-QOL and BPRS in electroacupuncture+Tibetan medicine group were significantly lower than those in lactulose group,electroacupuncture group,and Tibetan medicine group,while the BSFS score in electroacupuncture+Tibetan medicine group was significantly higher than those in other three groups(P<0.05).The BPRS scores in electroacupuncture group and Tibetan medicine group were significantly lower than that in lactulose group(P<0.05).The adverse reaction rates and TESS scores of electroacupuncture group,Tibetan medicine group and electroacupuncture+Tibetan medicine group were significantly lower than those of lactulose group(P<0.05).Conclusion For patients with constipation caused by antipsychotics,the application of electroacupuncture combined with Tibetan medicine Xixiezhouba Recipe is effective,which can effectively promote the recovery of defecation ability and improve the mental symptoms of patients with less adverse reactions.The curative effect of electroacupuncture combined with Tibetan medicine Xixiezhouba Recipe is better than that of electroacupuncture or Xixiezhouba Recipe alone.
Antipsychotic related constipationElectroacupunctureTibetan medicineXixiezhouba Recipe
万方数据
维普
