The correlations between functional connectivity changes of ventral striatum and clinical features in patients with melancholic depression
Objective To explore the changes of functional connectivity(FC)in ventral striatum(VS)in patients with melancholic depression and its correlations with clinical features.Methods A total of 59 depressive patients were selected and divided into melancholic depression group(group A,24 cases)and non-melancholic depression group(group B,35 cases).At the same time,31 matched healthy controls were recruited as control group.The patients were assessed with Hamilton Depression Scale-24 items(HAMD-24),Snaith Hamilton Pleasure Scale(SHAPS)and Temporary Experience of Pleasure Scale(TEPS).The resting-state magnetic resonance data of all subjects were gathered using 3.0T magnetic resonance imaging.The FC of the entire cerebrum was obtained using the VS as seeds to compare the differences of FC between patients with and without melancholic features.Finally,extracting the FC values of different cerebrum areas,to conduct correlation analysis between the FC values and clinical features.Results There existed significant difference in educational levels among three groups(P<0.05).Group A showed higher scores of MADRS,HAMD-24,SHAPS and lower scores of TEPS as well as consummatory pleasure than group B(P<0.05).There existed significant differences in FC values among left VS,left medial/lateral cingulate gyrus and right dorsolateral superior frontal gyrus,as well as between right VS and right middle temporal gyrus(P<0.05).Compared to group B,group A showed increased FC values between left VS and right dorsolateral superior frontal gyrus,left medial/lateral cingulate gyrus(P<0.05).Correlation analysis found that the FC value between left VS and left medial/lateral cingulate gyrus was positively correlated with SHAPS score in group A(P<0.05).Conclusion The incoordinate between VS and left medial/lateral cingulate gyrus may be the neuropathological basis of melancholic depression.
Melancholic depressionFunctional magnetic resonance imagingFunctional connectivityVentral striatum
万方数据
维普
