Effects of language training on overall cognitive function and executive function in patients with mild Alzheimer's disease
Objective To explore the effect of language training on overall cognitive function and executive function in patients with mild Alzheimer's disease(AD).Methods A total of 92 AD patients were selected and divided into ancient Chinese group(31 cases)with high intensity executive control training for ancient Chinese,English group(30 cases)with low intensity executive control training for English and modern Chinese group(31 cases)with no executive control training for modern Chinese according to random number table.All groups were treated for 3 months,and evaluated cognitive functions before treatment,and at the ends of 4 weeks and 3 months after treatment.They were all assessed with Mini-Mental State Examination(MMSE),Wsiconsin Card Sorting Test(WCST),Alzheimer Disease Assessment Scale-Cognitive(ADAS-cog),Quality of Life-Alzheimer Disease(QOL-AD),verbal fluency,and digit breadth.Results At the ends of 4 weeks and 3 months after treatment,the MMSE scores in three groups all significantly increased compared with those before treatment,and the MMSE scores in ancient Chinese group and English group were higher than that in modern Chinese group,while the MMSE score in ancient Chinese group was higher than that in English group(P<0.05).At the end of 3 months after treatment,the MMSE scores in three groups all significantly increased compared with those at the end of 4 weeks after treatment(P<0.05).At the ends of 4 weeks and 3 months after treatment,the ADAS-cog score and factor scores of error response and persistent error of WCST in three groups all decreased significantly compared with those before treatment,and all the above indicators at the end of 3 months after treatment were lower than those at the end of 4 weeks after treatment(P<0.05).At the ends of 4 weeks and 3 months after treatment,total scores of QOL-AD,verbal fluency and digit breadth as well as categories completed of WCST in three groups all increased significantly compared with those before treatment,and all the indicators above at the end of 3 months after treatment were higher than those at the end of 4 weeks after treatment(P<0.05).At the end of 3 months after treatment,the ADAS-cog score and factor scores of error response and persistent error of WCST in ancient Chinese group were the lowest,with English group in the middle and modern Chinese group showing the highest(P<0.05);total scores of QOL-AD,verbal fluency and digit breadth as well as categories completed of WCST in ancient Chinese group were the highest,with English group in the middle and modern Chinese group showing the lowest(P<0.05).Conclusion The effect of language training on the overall cognitive function and executive function in mild AD is good,and the ancient Chinese is the best,followed by English,and the effect of modern Chinese is relatively weak,which deserves clinical attention.
Language trainingMildAlzheimer's diseaseOverall cognitive functionExecutive functionAction effect
万方数据
维普
