Relationships between MIF and MBL2 gene polymorphisms and suicide attempts in patients with bipolar disorder
Objective To explore the relationships between macrophage inhibitory factor(MIF)and mannose-binding lectin 2(MBL2)gene polymorphisms and suicide attempts in patients with bipolar disorder(BD).Methods A total of 321 BD patients were selected as the research objects,and divided into BD with suicide attempt group(120 cases)and BD without suicide attempt group(201 cases)according to the definition of suicide attempt.The polymorphisms of MIF and MBL2 were detected by polymerase chain reaction-restriction fragment length polymorphism.Odds ratio(OR)and 95%confidence interval(95%CI)were calculated to evaluate the associations between MIF and MBL2 gene polymorphisms and suicide attempts in BD patients.Logistic regression analysis was used to explore the relationship between polymorphism loci genotype and BD susceptibility.Results There existed significant differences in the distribution frequencies of MIF and MBL2 genotypes between BD with and without suicide attempt groups(P<0.001).BD with suicide attempt group showed higher frequencies of A alleles of MIF and MBL2 genes,and lower frequencies of MIF G allele and MBL2 T allele than BD without suicide attempt group(P<0.05).MIF AA genotype and MBL2 A allele frequency were risk factors for suicide attempts in BD patients(P<0.05).Conclusion MIF AA genotype and MBL2 A allele frequency are correlated with suicide attempts in BD patients.
万方数据
维普
