Analysis on the validity of IDPN animal model in China based on NoteExpress
Objective To explore the research status of the validity of iminodipropionitrile(IDPN)animal model based on the related experimental literature,and to provide reference for the rational selection of animal model in the experimental study of Tic disorder(TD).Methods The Chinese and English databases from 2013 to 2023 were searched,and the animal experimental literature with IDPN as inducer by domestic scholars was selected for descriptive analysis.Results A total of 140 articles were included,and the analysis showed that the number of articles published by domestic scholars decreased slightly in recent 10 years,and dopamine,striatum and rat were the high-frequency keywords.Researchers often used SD male rats of 3～4 weeks old,and usually used IDPN[150 mg/(kg·d),250～300 mg/(kg·d)]for one week to establish TD model.The Diamond stereotyped behavior score≥1 indicated that the model was successful.The stereotyped movement of the head and neck of model rats could last for 8 weeks,and the contents of neurotransmitters and cytokines in brain tissue and blood were commonly used to evaluate the structural validity of the model.Most literature showed that the contents of DRD1,DRD2,5-HT,GLU in striatum and DA in blood of the model rats were increased,and the contents of DA and SERT in the striatum were decreased,while the contents of IL-1 and IFN-γ in brain tissue and blood were increased.There were some structural changes in brain tissue.Conclusion The IDPN model has a stable and sustained face validity,which involves the structural validity of neurotransmitter imbalance in CSTC loop and the predictive validity of antagonizing DRD2.
Tic disorderIDPNFace validityStructural validityPredictive validityAnimal model
NETL
NSTL
万方数据
