Changes and significance of serum thyroxine and inflammatory factors in patients with bone tumor complicated with depression
Objective To explore the changes and significance of serum thyroxine and inflammatory factors in patients with bone tumor complicated with depression.Methods A total of 110 patients with bone tumor were selected as case group and divided into combined group(n=32)and non-combined group(n=78)according to whether they were combined with depression,and 60 healthy subjects with normal physical examination during the same period were selected as control group.General data,depression scores,levels of serum thyroid hormones,inflammatory factor levels and treatment compliance of different groups were compared,and Pearson correlation was used to analyze the correlation between levels of serum thyroid hormone and inflammatory factors and depressive mood in patients with bone tumor.Results There existed significant differences in HAMD scores and levels of T3,TSH,IL-1β,IL-6,hs-CRP among three groups(P＜0.001).The combined group showed lower levels of T3 and TSH,and higher levels of IL-1β,IL-6,hs-CRP as well as HAMD score than non-combined group and control group(P＜0.05).Non-combined group showed lower levels of T3 and TSH,and higher levels of IL-1 β,IL-6,hs-CRP as well as HAMD score than control group(P＜0.05).The total treatment compliance rate of combined group was significantly lower than that of non-combined group(P＜0.05).Pearson correlation analysis showed that T3 and TSH were negatively correlated with HAMD score,while IL-1β,IL-6 and hs-CRP were positively correlated with HAMD score(P＜0.001).Conclusion The levels of serum thyroid hormones decrease and levels of inflammatory factors increase in patients with bone tumor complicated with depression,which are correlated with their depressive levels.This has important reference value for the diagnosis and treatment of bone tumor complicated with depression.
Bone tumorDepressionThyroid hormonesInflammatory factorsComplianceCorrelation
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