骨肿瘤合并抑郁患者血清甲状腺素、炎性因子水平变化及意义
Changes and significance of serum thyroxine and inflammatory factors in patients with bone tumor complicated with depression
杨鑫 1韩孝尚 1李敏 1王舒平1
作者信息
- 1. 068450 河北承德,围场满族蒙古族自治县医院
- 折叠
摘要
目的 探究骨肿瘤合并抑郁患者血清甲状腺素、炎性因子水平变化及意义.方法 选取骨肿瘤患者110例为病例组,根据是否合并抑郁将患者分为合并组(n=32)和非合并组(n=78),另选同期健康体检正常者60名为对照组.比较不同组别一般资料、抑郁评分、血清甲状腺激素、炎性因子水平及治疗依从性情况,并采用Pearson相关性分析骨肿瘤患者血清甲状腺激素、炎性因子水平与抑郁情绪的相关性.结果 三组HAMD评分、T3、TSH、IL-1β、IL-6、hs-CRP水平比较,差异均有统计学意义(P＜0.001).进一步两两比较结果显示,合并组T3、TSH水平低于非合并组与对照组,HAMD评分、IL-1β、IL-6、hs-CRP水平均高于非合并组与对照组(P＜0.05);非合并组T3、TSH水平低于对照组(P＜0.05),HAMD评分、IL-1β、IL-6、hs-CRP水平均高于对照组(P＜0.05).合并组总治疗依次率低于非合并组(P＜0.05).T3、TSH与HAMD评分呈负相关(P＜0.001),IL-1β、IL-6、hs-CRP水平与HAMD评分呈正相关(P＜0.001).结论 骨肿瘤合并抑郁患者血清甲状腺素水平降低,炎性因子水平升高,且与抑郁情绪呈显著相关,对于骨肿瘤合并抑郁的诊断和治疗具有重要的参考价值.
Abstract
Objective To explore the changes and significance of serum thyroxine and inflammatory factors in patients with bone tumor complicated with depression.Methods A total of 110 patients with bone tumor were selected as case group and divided into combined group(n=32)and non-combined group(n=78)according to whether they were combined with depression,and 60 healthy subjects with normal physical examination during the same period were selected as control group.General data,depression scores,levels of serum thyroid hormones,inflammatory factor levels and treatment compliance of different groups were compared,and Pearson correlation was used to analyze the correlation between levels of serum thyroid hormone and inflammatory factors and depressive mood in patients with bone tumor.Results There existed significant differences in HAMD scores and levels of T3,TSH,IL-1β,IL-6,hs-CRP among three groups(P＜0.001).The combined group showed lower levels of T3 and TSH,and higher levels of IL-1β,IL-6,hs-CRP as well as HAMD score than non-combined group and control group(P＜0.05).Non-combined group showed lower levels of T3 and TSH,and higher levels of IL-1 β,IL-6,hs-CRP as well as HAMD score than control group(P＜0.05).The total treatment compliance rate of combined group was significantly lower than that of non-combined group(P＜0.05).Pearson correlation analysis showed that T3 and TSH were negatively correlated with HAMD score,while IL-1β,IL-6 and hs-CRP were positively correlated with HAMD score(P＜0.001).Conclusion The levels of serum thyroid hormones decrease and levels of inflammatory factors increase in patients with bone tumor complicated with depression,which are correlated with their depressive levels.This has important reference value for the diagnosis and treatment of bone tumor complicated with depression.
关键词
骨肿瘤/抑郁/甲状腺素/炎性因子/依从性/相关性Key words
Bone tumor/Depression/Thyroid hormones/Inflammatory factors/Compliance/Correlation引用本文复制引用
基金项目
河北省承德市科技计划项目(202303A091)
出版年
2024
NETL
NSTL
万方数据