Research progress on the mechanisms by which natural phenolic compounds alleviate hyperuricemia
Hyperuricemia(HUA)is a metabolic disorder caused by the physiologic disorders in purine metabolism,resulting in increased serum uric acid levels,which can lead to gout in severe cases.HUA pathogenesis primarily involves enzyme dysfunction,urate transporter expression dysregulation,glucose and lipid metabolism disorders,and intestinal homeostasis disruption.Numerous studies have reported the effectiveness of natural polyphenols in alleviating hyperuricemia and gout.This article summarizes HUA pathogenesis and the mechanisms of action of polyphenolic compounds in reducing uric acid,to provide a theoretical basis for the research and development of uric acid-lowering drugs.
polyphenolshyperuricemiamechanism of actionresearch progress
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