Lignan constituents from the leaves of Dysoxylum gotadhora
To study the constituents of the leaves of Dysoxylum gotadhora,the 70% ethanol extract was separated using macroporous resin column chromatography,silica gel column chromatography,Sephadex LH-20 gel column chromatography,combined with semi-preparative HPLC and other methods.Four compounds 4,4′-dihydroxy-3,3′,5,5′-trtramethoxy-7,9′:7′,9-diepoxylignane(1),4′-hydroxy-3,4,5,3′-trtramethoxy-7,9′:7′,9-diepoxylignane(2),4′,4″-dihydroxy-3,3′,3″,5,5′,5″-hexamethoxy-7,9′:7′,9-diepoxy-4,8″-oxy-8,8′-sesquineolignan-7″,9″-diol(3),4′,4″-dihydroxy-3,3′,3″,5,5′-pentamethoxy-7,9′:7′,9-diepoxy-4,8″-oxy-8,8′-sesquineo lignan-7″,9″-diol(4)were isolated.Their structures were established by 1H NMR,13C NMR and MS spectroscopy techniques.Compounds 1 to 4 were obtained from the genus Dysoxylum for the first time.DPPH(1,1-diphenyl-2-picryhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl)radical scavenging rate were used to determine the antioxidant activity.The results show that lignans have significant DPPH free radical scavenging ability.
万方数据
维普
