Preparation and quality evaluation of collagen ceramide liposomes
In this study,egg yolk lecithin,cholesterol,and ceramide were used as film-forming materials to prepare collagen ceramide liposomes(CO-CS)by the thin film dispersion method.To optimize the process,encapsulation efficiency was used as the response value,and it was evaluated by influencing factors such as drug-lipid ratio,film-material ratio,ultrasonic time,and hydration time.Results showed that encapsulation efficiency reached 90.73% when the drug-lipid ratio,film-material ratio,and ultrasonic time were 1:16,4.3:1,and 8.5 min,respectively.Under these conditions,the particle size,polymer dispersity index(PDI),and zeta potential of CO-CS were(206.63±2.06)nm,0.187±0.010,and(34.90±0.82)mV,respectively.After 60 days of storage at room temperature in the dark,the encapsulation efficiency was 87.2% .Furthermore,the particle size,PDI,and zeta potential of CO-CS changed to(223.70±1.85)nm,0.174±0.013,and(33.51±2.10)mV,respectively.In summary,CO-CS produced in this study revealed high encapsulation efficiency and good stability,and the preparation process is reasonable and feasible.
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