首页|基于多糖及熵权-TOPSIS的灵芝药材质量评价研究

基于多糖及熵权-TOPSIS的灵芝药材质量评价研究

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基于多糖及熵权-逼近理想解排序法(TOPSIS)建立灵芝药材综合定量评价模型,为灵芝药材质量评价及优选最佳批次提供参考。首先测定同产地多批次灵芝药材粗多糖得率、糖组成、总糖含量、蛋白含量和糖醛酸含量,其次将数据进行无量纲化,最后采用熵权-TOPSIS法综合评价不同批次灵芝粗多糖得率质量并建立优选标准。根据各批次灵芝粗多糖得率、成分含量检测及聚类热图分析得出不同批次间灵芝药材粗多糖得率、总糖、糖醛酸含量差异较大,糖组成、蛋白含量差异相对较小,灵芝药材粗多糖得率及内在指标与基源无关联。熵权法赋权分析计算粗多糖得率权重系数最大为23。68%,其次为总糖 21。35%及糖醛酸含量 13。24%。TOPSIS排序结果及分组显示,栽培灵芝子实体、赤灵芝多糖综合评分较优。综上,同产地不同批次间灵芝药材质量差异较大,基于多指标综合评价的熵权-TOPSIS法可实现对灵芝多糖提取物药材来源快速、高效且准确的优选,在生产和质量全面评价中有广泛的应用前景,也可为其他中药材或饮片质量评价提供参考。
Quality evaluation of Ganoderma lucidum as a medicinal material based on polysaccharides and entropy-weighted TOPSIS
A comprehensive quantitative model that evaluates Ganoderma lucidum as a medicinal material was established based on polysaccharides and entropy-weighted technique for order preference by similarity to ideal solution(TOPSIS)to provide a reference for the quality evaluation of G.lucidum as a medicinal material and selecting the best batches.Initially,the yield,sugar composition,total sugar content,protein content,and uronic acid content of crude polysaccharides were determined formultiple batches of G.lucidum medicinal materials from the same origin.Subsequently,the data were nondimensionalized.Finally,entropy-weighted TOPSIS was used to comprehensively evaluate the quality of G.lucidum polysaccharides from different batches to establish the optimal standard.The yield,component content detection,and cluster heat map analysis of the polysaccharides showed that the polysaccharide yield and the total sugar and uronic acid content of G.lucidum medicinal materials from different batches varied significantly,whereas differences in the sugar composition and protein content were relatively minor.Polysaccharide yield and intrinsic indicators of the G.lucidum medicinal materials were not related to their origin.Entropy weight analysis showed that the polysaccharide yield weight coefficient was the largest at 23.68%,followed by total sugar at 21.35%and uronic acid content at 13.24%.The TOPSIS ranking and grouping results showed that cultivated G.lucidum fruiting bodies and red G.lucidum polysaccharides had better comprehensive scores.The quality of G.lucidum medicinal materials differ widely among different batches from the same origin.Entropy-weighted TOPSIS based on multi-index comprehensive evaluation achieved rapid,efficient,and accurate optimization of the source for G.lucidum polysaccharide extractasa medicinal material and has broad application prospects in production and comprehensive quality evaluation.This study provides a reference for the quality evaluation of other Chinese medicinal and decoction materials.

Ganoderma lucidumentropy-weighted TOPSIScluster analysisquality evaluationcrude polysaccharide yieldpolysaccharide compositionuronic acid

杨志城、孙彩虹、叶冠

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上海医药集团股份有限公司 中药研究所,上海 201203

灵芝 熵权-逼近理想解排序法 聚类分析 质量评价 粗多糖得率 糖组成 糖醛酸

2024

山东科学
山东省科学院

山东科学

CSTPCD
影响因子:0.266
ISSN:1002-4026
年,卷(期):2024.37(6)