Contamination Source and Risk Assessment of Polycyclic Aromatic Hydrocarbons in Chinese Medicinal Materials of the Same Origin as Food and Medicine
Objective To investigate the pollution status,traceability analysis and health risk of polycyclic aromatic hydrocarbons(PAHs)in four different medicinal parts of traditional Chinese medicines(TCMs).Methods The contamination detection,source analysis and health risk assessment of four different medicinal parts of TCMs were conducted by solid phase dispersion extraction pretreatment technology combined with HPLC-UV-FLD on-line detection technology.Results The pollution levels of 16 PAHs in different medicinal parts of TCMs were among ND-150.50 μg/kg,pyrene(Pyr)had the highest detection rate(51.43％)followed by chrysene(Chr,45.71％),and benzo(a)pyrene was not detected in all samples.Among 2-6 rings,4 rings accounted for the highest proportion(41.22％-50.95％),followed by 3 rings(22.23％-49.05％)and 2 rings(ND-36.56％),and 5-6 rings were not detected.Characteristic ratio analysis showed that petroleum,coal and biomass combustion were the main sources of PAHs.Fluoranthrene(Flu)contributed the most to carcinogenic toxicity(37.06％),followed by benzo(a)anthracene(BaA,23.59％).The lifetime carcinogenic risk range of TCMs was 2.90×10-8-1.75× 10-7,and ILCR value was less than 10-6.Conclusion PAHs contamination is common in four different medicinal parts of 35 TCMs which are used also as food,but its carcinogenic risk can be ignored.
traditional Chinese medicine(TCM)polycyclic aromatic hydrocarbonsedible TCMpollution traceabilityrisk assessment
万方数据
维普
