Measurement of Particle Size Distribution of Dexmedetomidine by Laser Light Scattering Method
Objective To establish a method for the detection of particle size distribution of dexmedetomidine bulk drug.Methods Using laser particle size analyzer,the particle size of dexmedetomidine bulk drug was detected by dry method.After optimization,the refractive index was set at 1.56,the height of funnel pool was set at 1.5 mm,the shading degree was set at 3.0%-4.0%,the pressure of dispersed gas was set at 0.8 bar,the injection speed was set at 50%,and the sample measurement time was set at 18 s.Results Under the optimized conditions,the RSDs of the results of particle size distribution were less than 2.0%,and the detected data were similar to the scanning results of electron microscope.Conclusion The method is simple,reproducible and accurate,and can be used for the determination of particle size of dexmedetomidine bulk drug.
万方数据
维普
