Determination of Heavy and Deleterious Metallic Elements in Niuhuang Jiedu Tablets and Assessment of Health Risk
Objective To determine the residual heavy metals and harmful metal elements in Niuhuang Jiedu Tablets and incorporate risk assessment into the evaluation of traditional Chinese medicine's exogenous contamination.Methods After microwave digestion,the contents of heavy metals and harmful metal elements in 60 batches of Niuhuang Jiedu Tablets were determined using ICP-MS.The preliminary health risk assessment was conducted following the procedures of hazard identification,hazard characterization,exposure assessment and risk description.Results Linear relationships for the four elements within their respective ranges were excellent(r≥0.997),with recoveries ranging from 87.3%to 93.1%(RSDs≤3.1%).None of the 60 batches of samples exceeded the limits for Cd,Cu and Pb,while the content of Hg exceeded the limit in 48.3%of the samples.Conclusion This method is sensitive and accurate,which can be used for examination of the residual residual heavy metals and harmful metal elements in Niuhuang Jiedu Tablets and scientific assessment of the health risks of heavy metals to human body,thus can provide research ideas for the safety evaluation of Niuhuang Jiedu Tablets.
万方数据
维普
