Study on Skin Care Efficacy of Hyaluronic Acid Oligosaccharides
Objective To verify the skin care efficacy of hyaluronic acid oligosaccharides in moisturizing,soothing,repairing,anti-inflammation and anti-oxidation.Methods The transdermal absorption ability of hyaluronic acid oligosaccharides was detected through suckling pig skin transdermal absorption experiment;the moisturizing and soothing effects of hyaluronic acid oligosaccharide were verified through zebrafish experiments;the repair effect of hyaluronic acid oligosaccharides was detected by construction of a 3D epidermal skin model;the role of hyaluronic acid oligosaccharides in inhibition of the expression of inflammatory factors was proved by the expression experiment of macrophage inflammatory factors;the antioxidant effect of hyaluronic acid oligosaccharides was revealed through the experiment on the scavenging ability of 1,1-diphenyl-2-picrylhydrazine radical(DPPH).Results The subcutaneous permeability of hyaluronic acid oligosaccharides was as high as 54%;the tail area of zebra fish was significantly increased and the number of neutrophils was significantly reduced;the concentrations of filamentous protein(FLG),closed protein 1(Claudin-1),hyaluronic acid receptor(CD44)and ceramide were all increased;the expression levels of IL-1β,TNF-α and PGE2 were decreased;the clearance rate of DPPH free radical was as high as 85.55%.Conclusion Hyaluronic acid oligosaccharids have significant effects of moisturizing and repairing,soothing and anti-inflammatory,and anti-oxidation,which provides new ideas and data support for the development and application of cosmetic raw materials.
hyaluronic acid oligosaccharidemoisturizing and repairingsoothing and anti-inflammatoryantioxidant
万方数据
维普
