Progress on Antitumor Mechanism of Dehydrocostus Lactone
Dehydrocostus lactone is a sesquiterpene lactone compound extracted from the root of Aucklandia lappa Decne in Asteraceae family,and it is one of the main active components with pharmacological activities such antimicrobial,anti-inflammatory,antiviral,anti-ulcer,antidiabetic and antitumor actuities.In recent years,dehydrocostus lactone has attracted wide attention in the field of antitumor therapy.It is found that dehydrocostus lactone can inhibit the proliferation and migration ability of tumor cells,and has inhibitory effect on lung cancer,cervical cancer and other cancers.Its anti-tumor mechanism mainly includes inhibition of tumor cell proliferation,inhibition of tumor cell invasion and migration,induction of tumor cell apoptosis and reversal of tumor cell multidrug resistance.In this paper,the antitumor mechanism of dehydrocostus lactone is reviewed in detail in recent years,aiming to provide new theoretical support,new ideas and references for this class of drugs in clinical tumor therapy.
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