Research Progress on Anti-tumor Molecular Mechanism of Arsenic Trioxide
Arsenic trioxide(As2O3)was initially concerned by researchers for the treatment of acute promyelocytic leukemia(APL),and has since been widely used in the treatment of a variety of malignant tumors.The anti-tumor mechanism of As2O3 mainly includes:inducing apoptosis and cell cycle arrest of tumor cells,inhibiting angiogenesis,targeting cancer stem cells and reversing chemotherapy resistance of tumor cells.Based on the latest research results,the anti-tumor molecular mechanism of As2O3 is reviewed in this paper,which aims to provide ideas for further research and clinical application of its anti-tumor activity.
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