Objective To establish an HPLC method for the determination of related substances in Ibuprofen Oral Suspension.Methods An Spherisorb ODS2 column(4.6 mm×150 mm,5 μm)was used,with phosphoric acid-tetrahydrofuran-acetonitrile-water(0.5:10:340:650)as the mobile phase.The flow rate was 2.0 ml/min,the detection wavelength was 214 nm and the column temperature was 30℃.The injection volume was 20 μl.Results Ibuprofen and its impurities were well separated.The linear correlation coefficients were all greater than 0.999.The average recoveries were in the range of 98%-102%.Conclusion The method is simple,rapid,accurate,and is suitable for the determination of related substances in Ibuprofen Oral Suspension,which is conductive to quality control.
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