首页|软膏基质白凡士林的流变学性质研究

软膏基质白凡士林的流变学性质研究

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目的 研究软膏基质白凡士林的流变学性质.方法 采用Kinexus旋转流变仪,通过稳态剪切与振荡剪切两种测量模式对白凡士林流动曲线、屈服应力、触变性、线性黏弹性、蠕变恢复等流变学性质进行研究.结果 流动曲线测定采用PU20磨砂夹具,间隙0.5 mm,温度(32±0.1)℃,1,10,100 s-1的剪切黏度测定数据RSD值分别为14.59%,4.64%,3.42%,于1~100 s-1范围内扫描,白凡士林黏度随剪切速率增加而降低;黏弹性测定采用PU20磨砂夹具,间隙0.5 mm,温度(25±0.1)℃,剪切频率10 Hz时G'、G"的RSD值分别为10.89%,9.46%.剪切应变0.01%~0.2%范围内为线性黏弹区,在该范围内,弹性模量略大于黏性模量.结论 采用旋转流变仪测定白凡士林流变学性质方法简单、准确、精密度好.白凡士林具有剪切变稀的流变特性,表现为非牛顿流体,在测定条件下,倾向于类固体的黏弹性特征,且具有较强的触变性和蠕变恢复能力.
Study on Rheological Properties of Ointment Base White Vaseline
Objective To investigate the rheological properties of ointment base white vaseline.Methods The rheological curves,yield stress,thixotropy,linear viscoelasticity and creep recovery of white vaseline were studied under steady shear mode and oscillatory shear mode by Kinexus rotational rheometer.Results The rheological curves were measured using PU20 frosted fixture.The gap was 0.5 mm,the temperature was set at(32±0.1)℃,then the RSDs of shear viscosity test results at different shear rates including 1,10 and 100 s-1 were 14.59%,4.64%and 3.42%,respectively.In the range of 1-100 s-1,the viscosity decreased with the increase of shear rate.The viscoelasticity was measured using PU20 frosted fixture.The gap was 0.5 mm,the temperature was set at(25±0.1)℃.When the shear rate was 10 Hz,the RSDs of G'and G"were 10.89%and 9.46%,respectively.When the shear strain ranged from 0.01%to 0.2%,white vaseline showed linear viscoelastic characteristics,and the elastic modulus was always slightly higher than the viscous modulus.Conclusion The method is simple,accurate and reproducible.White vaseline has a rheological behavior of shear thinning and is a non-Newtonian fluid.Under the measure conditions,white vaseline tends to have solid-like viscoelastic characteristics,and has strong thixotropy and creep recovery ability.

white vaselinerheometersteady shearoscillatory shearrheological property

王丽丽、祝美华、陈建英

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山东省药学科学院,山东济南 250101

新型缓控释制剂与药物靶向递送山东省工程研究中心,山东济南 250101

国家药监局药物制剂技术研究与评价重点实验室,山东济南 250101

白凡士林 旋转流变仪 稳态剪切 振荡剪切 流变学性质

2024

食品与药品
山东省生物药物研究院

食品与药品

CSTPCD
影响因子:0.537
ISSN:1672-979X
年,卷(期):2024.26(6)