Small interfering RNA(siRNA)drugs can specifically regulate pathogenic target genes,which have good efficacy and minimal side effects.The main advantages of nanocarrier systems in siRNA delivery are low cytotoxicity,high transfection efficiency,good stability,and the ability to perform specific delivery through active and passive targeting and protect nucleic acid molecules from enzymatic degradation.This article reviews the application progress of siRNA loaded nanodelivery systems in tumor therapy,aiming to provide new ideas for tumor treatment.
关键词
肿瘤/siRNA/核酸递送/纳米递送系统
Key words
tumor/siRNA/nucleic acid delivery/nanodelivery system
维普
万方数据