肿瘤源性外泌体在头颈鳞状细胞癌微环境中的免疫调节作用
Immunomodulatory roles of tumor-derived exosomes in the microenvironment of head and neck squamous cell carcinoma
宋斐 1宋昊 1李玉梅 2牟亚魁 2宋西成2
作者信息
- 1. 滨州医学院 第二临床医学院,山东 烟台 264100;青岛大学附属烟台毓璜顶医院/山东省耳鼻喉疾病临床医学研究中心 耳鼻咽喉头颈外科,山东 烟台 264099
- 2. 青岛大学附属烟台毓璜顶医院/山东省耳鼻喉疾病临床医学研究中心 耳鼻咽喉头颈外科,山东 烟台 264099
- 折叠
摘要
头颈鳞状细胞癌是最常见的恶性肿瘤之一,肿瘤源性外泌体可通过直接与细胞受体相互作用或与质膜发生质膜融合参与免疫细胞调控,在头颈鳞状细胞癌的调控中发挥作用.肿瘤源性外泌体不仅可以抑制杀伤性免疫细胞对肿瘤的杀伤作用,还可以负向调节免疫抑制性细胞,促进肿瘤细胞发生免疫逃逸,以此调控肿瘤发生、发展以及远处转移.论文综述肿瘤源性外泌体在头颈鳞状细胞癌微环境中调控不同类型免疫细胞的研究进展.通过研究肿瘤源性外泌体在肿瘤微环境中的调控作用,为实现外泌体递药、肿瘤靶向治疗提供新策略.
Abstract
Head and neck squamous cell carcinoma is one of the most common malignancies.Tumor-derived exosomes can partici-pate in immune cell regulation through direct interaction with cell receptors or fusion with plasma membrane in immune cells,which plays animportant role in the regulation of head and neck squamous cell carcinoma.Tumor-derived exosomes can not only inhibit the effects of killing immune cells on tumors,but also negatively regulate immunosuppressive cell response to promote immune escape of tumor cells,and thus regulate the process of tumorigenesis,development,and distant metastases.This review summarizes the lat-est research on tumor-derived exosome functions in regulating different types of immune cells in the microenvironment of head and neck squamous cell carcinoma.Through the exploration of tumor-derived exosome regulation of the tumor microenvironment,we aim to realize new strategies of exosome drug delivery and tumor targeted therapy.
关键词
头颈鳞状细胞癌/肿瘤源性外泌体/杀伤性免疫细胞/免疫抑制性细胞/肿瘤微环境Key words
Head and neck squamous cell carcinoma/Tumor-derived exosomes/Killing immune cell/Inhibitory immune cells/Tumor microenvironment引用本文复制引用
基金项目
山东省重大创新工程项目(2022CXPT023)
出版年
2024
NETL
NSTL
维普
万方数据