他汀类药物在过敏性疾病中的治疗作用探讨
Therapeutic role of statins in allergic diseases
董淋 1温思露 1邓玉琴 1陶泽璋2
作者信息
- 1. 武汉大学人民医院 耳鼻咽喉头颈外科,湖北 武汉 430060
- 2. 武汉大学人民医院 耳鼻咽喉头颈外科,湖北 武汉 430060;武汉大学人民医院 耳鼻咽喉头颈外科中心实验室,湖北 武汉 430060
- 折叠
摘要
过敏性疾病是一类常见的慢性病,其发病率持续升高,严重影响患者生活质量.治疗有效且价格合理的新型药物的研发工作需要持续进行.近年来,他汀类药物被发现除了降低血液中的脂质水平外,还有抗炎、抗氧化、免疫调节等多效作用,一系列的动物实验及临床试验均证实他汀类药物对过敏性炎症有治疗作用.他汀类药物在过敏性疾病中的具体作用机制、临床效果是现在研究的重点,对于该药的临床应用有重要意义.论文将他汀类药物在过敏性疾病的临床干预中的研究进展作一介绍,并综述他汀类药物在过敏性疾病中的作用机制.
Abstract
Allergic diseases are a common group of chronic conditions with continuously increasing prevalence.These diseases ad-versely affect the quality of life of patients.The research and development of new drugs with effective treatment and reasonable price need to continue.In recent years,in addition to lowering blood lipid levels,statins have pleiotropic properties and exert anti-inflam-matory,antioxidant,and immunomodulatory effects.A series of animal experiments and clinical trials have confirmed the therapeu-tic effects of statins against allergic inflammation.Their specific mechanism of action and clinical effects in allergic diseases are the focus of current research,which is of great significance for the clinical application of them.In this article,the research progress of clinical intervention of statins in the treatment of allergic diseases is introduced,and the research progress of the therapeutic mecha-nism of statins in allergic diseases is reviewed.
关键词
他汀类药物/过敏性疾病/免疫/血脂异常/甲羟戊酸Key words
Statins/Allergic Diseases/Immunity/Dyslipidemia/Mevalonic acid引用本文复制引用
基金项目
国家自然科学基金(81970860)
国家自然科学基金(81870705)
出版年
2024
NETL
NSTL
维普
万方数据