Objective To investigate the expression and significance of inflammatory cells,CXC chemokine ligand 10(CXCL10),and interferon-γ(IFN-γ)in the antrochoanal polyp(ACP).Methods A total of 58 samples were collected from the First Affilia-ted Hospital of Hebei North University between October 2015 and July 2020,including 40 cases of ACP and 18 case of maxillary sinus cysts.Preoperative serum and surgical samples were collected.Paraffin embedding and HE staining were performed on surgical specimens,and the number and percentage of various inflammatory cells were counted.The epithelial hyperplasia of patients with ACP was comprehensively scored.The expression of CXCL10 and IFN-γ in ACP and control groups was observed by immunohisto-chemical staining.The enzyme-linked immunosorbent assay detected the protein concentration of serum CXCL10 in two groups,and the correlation between protein concentration and inflammatory cells in peripheral blood of the two groups was analyzed.Results HE staining revealed obvious epithelial remodeling and heterogeneity with inflammatory cell infiltration,primarily neutrophils,lym-phocytes,and plasma cells in group ACP.A positive correlation was found between ACP neutrophils and lymphocytes with the anal-ysis by routine blood examination.Immunohistochemistry showed that CXCL10 and IFN-γ in the experimental group were strongly positive compared with those in the control group.The concentration of CXCL10 was(32.15±4.60)pg/mL vs(12.11±3.54)pg/mL in ACP and control groups as determined by ELISA(P＜0.05).Conclusion The expression of CXCL10 and IFN-γ were significant-ly upregulated in the ACP group,which may be related to non-type Ⅱ inflammation,especially Th1 inflammatory factors.
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