TLR4/NF-κB通道在糖尿病视网膜病变中的作用
Role of Toll-like receptor 4/nuclear transcription factor-κB channels in diabetic retinopathy
伦英俊 1陈晨 2高宏程 2范清琳 3邰仁清1
作者信息
- 1. 潍坊医学院 临床医学院,山东 潍坊 261000
- 2. 临沂市人民医院 眼科,山东 临沂 276000
- 3. 山东第一医科大学(山东省医学科学院)研究生处,山东 泰安 271000
- 折叠
摘要
糖尿病视网膜病变(diabetic retinopathy,DR)是一种由糖尿病引起的微血管并发症,也是导致患者失明的首要原因.其发病机制受多种因素影响,例如免疫炎症、氧化应激、多元醇途径等.目前认为免疫炎症机制在DR的发生发展起重要作用.Toll样受体4(Toll-like receptor 4,TLR4)/核转录因子-κB(nuclear factor kappa B,NF-κB)通路是介导炎症因子释放的重要途径,在免疫炎性机制中发挥关键作用.目前不少研究证实抑制TLR4/NF-κB信号通路可有效减轻DR.本文就TLR4/NF-κB通道在DR中的作用进行综述,可为治疗DR提供新的靶点.
Abstract
Diabetic retinopathy(DR)is a microvascular complication caused by diabetes mellitus and is the primary cause of blind-ness in patients.Its pathogenesis is influenced by various factors,such as immune inflammation,oxidative stress,and polyol path-ways.Currently,immune-inflammatory responses are considered to play important roles in the development of DR.The Toll-like re-ceptor 4(TLR4)/nuclear transcription factor-κB(NF-κB)pathway mediates the release of inflammatory factors and plays a key role in inflammatory mechanisms.Several studies have demonstrated that inhibition of the TLR4/NF-κB signaling pathway can ef-fectively treat DR.This review addresses the role of TLR4/NF-κB channels in DR,which may provide novel treatment targets for this disease.
关键词
糖尿病视网膜病变/Toll样受体4/核转录因子κB/小胶质细胞/炎症Key words
Diabetic retinopathy/Toll-like receptor 4/Nuclear factor kappa B/Microglia/Inflammation引用本文复制引用
基金项目
临沂市人民医院研究生培养基金(YJS2023076)
出版年
2024
NETL
NSTL
万方数据