石墨烯养护鼻罩结合尘螨的皮下特异性免疫治疗在尘螨变应性鼻炎患者中的应用分析
Graphene cured nasal mask combined with subcutaneous specific immunotherapy of dust mite in patients with dust mite allergic rhinitis application analysis
张丽净 1冯晓星 1刘南仙 1赵辉明 1陈月华1
作者信息
- 1. 石家庄市人民医院 耳鼻咽喉头颈外科,河北 石家庄 050030
- 折叠
摘要
目的 探讨石墨烯养护鼻罩结合尘螨的皮下特异性免疫治疗用于尘螨变应性鼻炎患者的效果.方法 选取 102 例尘螨变应性鼻炎患者,按照随机数字表法分为对照组(51 例)、观察组(51 例),对照组采用单纯尘螨的皮下特异性免疫治疗(尘螨变应原疫苗免疫治疗),观察组采用尘螨的皮下特异性免疫治疗与石墨烯养护鼻罩治疗,比较两组临床效果、不良反应、临床症状评分、免疫功能指标、炎症因子指标、生活质量评分.结果 观察组总有效率高于对照组(Z=5.005,P=0.025).与对照组相比,治疗前后观察组临床症状评分、免疫功能指标、炎症因子、生活质量评分差值具有统计学意义(P均<0.05).两组不良反应发生率差异无统计学意义(χ2=0.614,P=0.433).结论 与单纯尘螨的皮下特异性免疫治疗相比,石墨烯养护鼻罩结合尘螨变应原疫苗可缓解尘螨变应性鼻炎患者的临床症状,提高治疗效果.
Abstract
Objective To analyze the effect of graphene-cured nasal mask combined with subcutaneous specific immunotherapy of dust mite in patients with dust mite allergic rhinitis.Methods A total of 102 patients with dust mite allergic rhinitis were selected and divided into two groups according to the random number table method,namely the control group(51 cases)and the observation group(51 cases),the control group was treated with subcutaneous specific immunotherapy(dust mite allergen vaccine immuniza-tion)with dust mites alone,and the subcutaneous specific immunotherapy+graphene cured nasal mask treatment of dust mites in the observation group was compared to compare the clinical effects,adverse reactions,clinical symptom scores,immune function indexes,Inflammatory factor indexes,quality of life scores.Results The total effective rate of the observation group was higher than that of the control group(Z=5.005,P=0.025).Compared with the control group,the difference in clinical symptom scores,immune function indicators,inflammatory factors,and quality of life scores was higher in the observation group before and after treatment(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(χ2=0.614,P=0.433).Conclusion Compared with dust mite allergen vaccine alone,graphene-cured nasal mask combined with dust mite allergen vaccine can alleviate the clinical symptoms and improve the treatment effect of dust mite allergic rhinitis patients.
关键词
石墨烯养护鼻罩/尘螨变应原疫苗/尘螨变应性鼻炎/炎症因子/免疫功能Key words
Graphene curing nose mask/Dust mite allergen vaccine/Dust mite allergic rhinitis/Inflammatory factors/Immune function引用本文复制引用
基金项目
石家庄市科学技术研究与发展计划(191461113)
出版年
2024
NETL
NSTL
万方数据