血小板-淋巴细胞比值与喉鳞状细胞癌预后相关性的Meta分析
A meta-analysis of the correlation between platelet-lymphocyte ratio and prognosis of laryngeal squamous cell carcinoma
王凯健 1陈雪生 1王威1
作者信息
- 1. 启东市人民医院/南通大学附属启东医院 耳鼻咽喉头颈外科,江苏 启东 226200
- 折叠
摘要
目的 采用Meta分析探讨血小板-淋巴细胞比值(platelet-lymphocyte ratio,PLR)与喉鳞状细胞癌(laryngeal squamous cell carcinoma,LSCC)患者预后的相关性,为临床预测患者预后,优化治疗策略提供循证依据.方法 在PubMed、Web of Sci-ence、中国知网、维普及万方等数据库检索国内外发表的PLR与LSCC预后相关性的研究,提取患者预后指标的原始数据,使用Stata12.0 统计软件对数据进行Meta分析.结果 共纳入 14 项研究,Meta分析结果显示PLR越高患者总生存期(HR=1.46,95%CI:1.34～1.58,P<0.001)、无复发生存期(HR=1.37,95%CI:1.25～1.50,P<0.001),无进展生存期(HR=1.52,95%CI:1.11～2.08,P<0.001)、无病生存期(HR=1.15,95%CI:1.04～1.27,P<0.001)、癌症特异性生存期(HR=1.24,95%CI:1.12～1.38,P<0.001)越差,差异具有统计学意义.结论 PLR值与LSCC患者预后密切相关,PLR值越高,患者预后越差,PLR值可作为评估患者预后的有效指标.
Abstract
Objective To investigate the correlation between platelet-lymphocyte ratio(PLR)and the prognosis of patients with laryngeal squamous cell carcinoma(LSCC)by Meta-analysis,and to predict the prognosis of patients.To provide evidence-based evidence for optimizing treatment strategies.Methods PubMed,Web of Science,CNKI,VIP and Wan fang databases were searched for studies on the correlation between PLR and the prognosis of LSCC.The raw data of prognostic indicators were extracted,and Meta-analysis was performed using Stata12.0 statistical software.Results A total of 14 studies were included.The results of Meta-analysis showed that overall survival of patients with higher PLR(HR=1.46,95%CI:1.34-1.58,P<0.001),recur-rence-free survival(HR=1.37,95%CI:1.25-1.50,P<0.001),progression-free survival(HR=1.52,95%CI:1.11-2.08,P<0.001),disease-free survival(HR=1.15,95%CI:1.04-1.27,P<0.001),and the worse(HR=1.24,95%CI:1.12-1.38,P<0.001).Conclusion The prognosis of patients is closely related to PLR value.The higher the PLR value,the worse the prognosis of patients,PLR value is an effective indicator to preliminarily judge the prognosis of patients.
关键词
血小板-淋巴细胞比值/喉鳞状细胞癌/预后/Meta分析Key words
Platelet-lymphocyte ratio/Laryngeal squamous cell carcinoma/Prognosis/Meta-analysis引用本文复制引用
基金项目
南通市卫生健康委青年指令性课题(QN2023062)
出版年
2024
NETL
NSTL
万方数据