摘要
干眼是目前严重危害人类视觉生活质量的眼表疾病之一,近年其发病率逐年升高,但具体发病机制目前尚未明确.眼表炎症反应、氧化应激、眼表细胞凋亡、营养保护因子减少等因素在干眼发生中的作用备受关注.色素上皮衍生因子(pigment epithelial derived factor,PEDF)是一种天然的新生血管抑制剂,具有抑制炎症反应、抗氧化应激反应、抗细胞凋亡及神经营养和细胞保护等生物学功能.最新的研究表明PEDF在干眼的发病机制中发挥重要作用.本文主要对PEDF在干眼发生、发展中发挥的机制及潜在的治疗作用做简要概述,为进一步研究PEDF在干眼中的作用并为干眼的治疗提供新思路.
Abstract
Dry eye is one of the ocular surface diseases seriously endangering the quality of human vision.In recent years,its inci-dence rate has increased year by year.However,the specific pathogenesis has not been clarified yet.The effects of ocular surface in-flammation,oxidative stress,apoptosis of ocular surface cells,and reduction of nutritional protective factors in the occurrence of it have attracted much attention.Pigment epithelial derived factor(PEDF)is a natural neovascular inhibitor,which has biological functions such as inhibiting inflammatory response,resisting stress response,anti apoptosis,nourishing nerves and protecting cells.The latest studies suggest that PEDF plays important roles in the pathogenesis of it.In this review,the mechanism and potential ther-apeutic effects of PEDF in the occurrence and development of dry eye are briefly summarized,so as to further study the role of PEDF in dry eye and provide new ideas for the treatment of it in the future.
基金项目
兰州大学第二医院萃英学子科研培育计划(CYXZ2021-07)
兰州大学第二医院萃英学子科研培育计划(CYXZ2023-09)
兰州大学医学教育创新发展项目()
NETL
NSTL
万方数据